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ported by grants from the National Foundation-March of Dimes. A professor of pediatrics and microbiology at the University of Minnesota, he has been a National Foundation grantee since 1960.
He and his associates have been conducting a variety of research projects related to birth defects of the immunity system and bodily defenses. To correct such defects, Dr. Good wanted to transplant healthy bone marrow into patients with such defects in order to reconstitute their immunologic systems.
Other investigators had considered this line of treatment, but previous attempts at transplantation had failed because of overwhelming, and ultimately fatal—graft-vs.-host reactions.
Most people are familiar with the concept of the GVH reaction today because of the publicity that heart transplants have received. When foreign material enters the body, antibodies tend to build up and attack or reject this material. This is the "rejection reaction” —the body rejects the donor material.
The GVH reaction is essentially the opposite of the rejection reaction. The antibody cells of the graft or donor material attack the host body into which it is transplanted.
The reaction can be minimized only by matching the donor material as closely as possible to that of the patient.
94.8%